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The study examined e-health (ICT) acceptance on employee performance in Ondo State specialist hospitals. The study investigated the challenges facing acceptance of e-health by employees of state specialist hospitals and also examined the effect of acceptance of e-health on the performance of employees in state specialist hospitals. The purpose was to access how ehealth can help improve service delivery in teaching hospitals in the study area. The work is anchored on the Technology Acceptance Model (TAM) which is an adoption model focusing on users’ acceptance of information systems or computer technologies. The aim of this theory is to describe factors that determine technology acceptance and information technology usage behavior. Primary data was used for the study. The questionnaire was used for the collection of data. The number of respondents for the study is 318. Descriptive and inferential statistics were used for data analysis. The research findings using descriptive analysis showed that a lot of challenges exist and affect the degree of acceptance of e-health by the employees in the study area. The result also showed that e-health (ICT) acceptance has a positive significant effect on employee performance in the state specialist hospitals in the study area. The hypothesis stated was tested at a 0.05 level of significance to determine the effect of e-health acceptance on employees’ performance using regression analysis and it was rejected because the pvalue was less than 0.05 (Beta=0.208, t=7.149, Sig=0.000, p<0.05). The study, therefore, concludes that there are challenges that affect the acceptance of ehealth (ICT) and that there is a significant positive effect of e-health acceptance and performance of employees in the state specialist hospitals in Ondo State, Nigeria.

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